Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

vasculară

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Grupul de cercetare în sănătatea fetală, Divizia de Obstetrică și Ginecologie, Spitalul Guy's King's St Thomas, Lambeth Palace Road, Londra SE1 7EH, Marea Britanie

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Grupul de cercetare în sănătatea fetală, Divizia de Obstetrică și Ginecologie, Spitalul Guy's King's St Thomas, Lambeth Palace Road, Londra SE1 7EH, Marea Britanie

Center for Developmental Origins of Health & Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK

Abstract

Restricția proteinelor în sarcina șobolanilor programează dezvoltarea tensiunii arteriale sistolice crescute și a disfuncției vasculare la descendenți. Un studiu recent a arătat că hipertensiunea este inversată prin suplimentarea cu glicină maternă. Nu se știe dacă acest efect protector se exercită direct asupra embrionului și fătului, sau indirect prin efecte asupra mamei, deși am arătat anterior anomalii ale vasculaturii materne. Am testat ipoteza conform căreia reîncărcarea dietetică a glicinei ar inversa disfuncția endotelială la barajele de șobolani însărcinate cu proteine, folosind miografie cu sârmă. Afectare a acetilcolinei‐ (P